Products for Research Use Only
RegisterLogin

MHES0488A

CAT: 0931-T9901A-980-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T9901A-980-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
EGFR, DNA Alkylator/Crosslinker
Related Pathways
DNA Damage/DNA Repair, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
MHES0488A is a selective humanized antibody targeting HER2, with a KD value of 0.8 nM. It constitutes the antibody portion of DHES0815A. Upon cellular internalization, MHES0488A is transported to lysosomes, releasing PBD-monoamide into the nucleus, where it alkylates DNA, inducing DNA damage and apoptosis. It shows potential for research in cancers such as HER2-positive breast cancer and gastric cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-P991236MHES0488A

Popular Products