BGB-A445

• Target:

  NF-?B|||OX Receptor

• Related Pathways:

  NF-?B|||Neuroscience|||GPCR/G Protein

• Bioactivity:

  BGB-A445 is a humanized non-ligand blocking agonistic OX40 monoclonal antibody with high affinity for OX40. It activates the downstream NF-?B pathway, inducing activation, proliferation, and survival of immune cells. BGB-A445 significantly depletes regulatory T cells in a dose-dependent manner via antibody-dependent cellular cytotoxicity (ADCC) . In the MC38 mouse model, BGB-A445 demonstrates potent, dose-dependent antitumor efficacy and is applicable in cancer studies, such as colorectal adenocarcinoma.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3033874-57-3