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HGS101

CAT: 0931-T9901A-1812-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1812-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
CCR, HIV Protease
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Microbiology/Virology, Proteases/Proteasome
Bioactivity
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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