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Zaptuzumab

CAT: 0931-T9901A-1802-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1802-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2378046-35-4
Target
Autophagy, JNK, ATG, Apoptosis, Caspase, Akt, TNF
Related Pathways
Autophagy, Proteases/Proteasome, Apoptosis, Cytoskeletal Signaling, MAPK, PI3K/Akt/mTOR signaling
Bioactivity
Zaptuzumab (AD5-10) is a humanized monoclonal antibody targeting death receptor 5 (DR5) with high selective binding affinity. It specifically induces cancer cell death through caspase-mediated apoptosis and autophagic cell death (ACD) . Zaptuzumab can activate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) . Additionally, it induces reactive oxygen species (ROS) production and reduces glutathione (GSH) levels. In various xenograft mouse tumor models, Zaptuzumab has demonstrated significant tumor growth inhibition and favorable safety profiles.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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