GC1118

CAT: 0931-T9901A-1771-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T9901A-1771-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PERK, Akt, EGFR

Related Pathways

Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, PI3K/Akt/mTOR signaling

Bioactivity

GC1118 (GC-1118A) is a fully human anti-EGFR monoclonal antibody with a KD value of 0.16 nM against EGFR. It potently inhibits signal transduction triggered by both high-affinity and low-affinity EGFR ligands. GC1118 exhibits strong antiproliferative activity in both KRAS wild-type and KRAS mutant cells. It can penetrate the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to reach tumor sites and demonstrates excellent antitumor effects in various mouse xenograft models. GC1118 is applicable for cancer studies, including colorectal cancer.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
HY-P991571	GC1118

GC1118

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