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VX5

CAT: 0931-T9901A-1765-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1765-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CXCR
Related Pathways
Immunology/Inflammation, Autophagy, GPCR/G Protein
Bioactivity
VX5 is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. It significantly inhibits human CXCL13-mediated CXCR5 internalization and blocks the CXCL13-dependent chemotaxis and migration of both human and mouse B cells (with EC50 values of 105 nM for human tonsil cells and 253 nM for pre-B-697-hCXCR5 cells) . VX5 is applicable in the study of autoimmune diseases such as multiple sclerosis and arthritis, as well as cancers like gastric lymphoma and colon cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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