VTX-0811

• Target :

  TNF|||NF-?B|||c-Myc

• Related Pathways :

  Apoptosis|||Cell Cycle/Checkpoint|||NF-?B

• Bioactivity :

  VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-?/NF-?B and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C