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VTX-0811

CAT: 931-T9901A-1683-01Size: 1 mgDry Ice: NoHazardous: No
1 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TNF|||NF-?B|||c-Myc
Related Pathways
Apoptosis|||Cell Cycle/Checkpoint|||NF-?B
Bioactivity
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-?/NF-?B and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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HY-P991432VTX-0811
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