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Z21115

CAT: 0931-T89970-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89970-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2958668-54-5
Target
PDE
Related Pathways
Metabolism
Bioactivity
Z21115 is an orally effective phosphodiesterase 4 (PDE4) inhibitor that can inhibit PDE4D7 with an IC50 of 10.5 nM. It suppresses the expression of IL-6, TNF-α, and iNOS induced by Lipopolysaccharide. In a DSS-induced mouse colitis model, Z21115 demonstrates anti-inflammatory activity without significant toxicity at doses up to 1 g/kg.
Smiles
FC(F)OC1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)C3=CN(N=C13)C4CC4
Molecular Formula
C20H20F2N2O4
Molecular Weight
390.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-161936Z21115

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