Products for Research Use Only
RegisterLogin

YLL545

CAT: 0931-T89909-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T89909-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1423126-69-5
Target
STAT, ERK, Apoptosis, VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, MAPK, Stem Cells, Apoptosis, Angiogenesis
Bioactivity
YLL545 is an inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) . It inhibits VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling mediators (such as phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC) . Additionally, YLL545 suppresses HUVEC proliferation, migration, invasion, and angiogenesis. It also induces apoptosis and inhibits tumor growth in a mouse model of breast cancer.
Smiles
O=C(NC1=CC=C(OC2=NC=NC=3NN=CC23)C=C1)NC4=CC=CC(=C4)C(F)(F)F
Molecular Formula
C19H13F3N6O2
Molecular Weight
414.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-164551YLL545

Popular Products