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Isoforretin A

CAT: 0931-T89898-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89898-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2231757-68-7
Target
Reactive Oxygen Species, Apoptosis
Related Pathways
NF-κB, Metabolism, Apoptosis, Immunology/Inflammation
Bioactivity
Isoforretin A is a potent inhibitor of thioredoxin-1 (Trx1) with significant biological activity, inducing anti-tumor effects mediated by reactive oxygen species (ROS) . The compound inhibits Trx1 activity by covalently binding to the activation site residues Cys32/Cys35, which triggers ROS accumulation, leading to DNA damage and apoptosis (Apoptosis) in cancer cells. Additionally, Isoforretin A has demonstrated the ability to suppress the growth of HepG2 tumors in a mouse hepatic cell carcinoma xenograft model.
Smiles
C[C@]12[C@]3([C@]4(C[C@@]([C@@H](OC(C)=O)[C@@H]3OC(C)=O)(C(=C)C4=O)[H])C[C@@H](O)[C@@]1(C(C)(C)[C@@H](OC(C)=O)[C@@H](OC(C)=O)C2)[H])[H]
Molecular Formula
C28H38O10
Molecular Weight
534.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19237646-01Isoforretin A

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