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A-1208746

CAT: 0931-T89872-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89872-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1668553-23-8
Target
Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
A-1208746 is an inhibitor of MCL-1 with a Ki value of 0.454 nM. This compound effectively activates caspase-3/-7, induces apoptosis in H929 cells, and reduces mitochondrial membrane potential. Additionally, A-1208746 synergizes with Navitoclax, making it applicable in cancer research.
Smiles
O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)C)C)C)C2N1CCN6CCOCC6)CCCOC7=CC=CC=8C=CC=CC78
Molecular Formula
C45H52N6O7S
Molecular Weight
821
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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