O-GlcNAcase-IN-2

CAT:

931-T89845-01

Size:

10 mg

Price:

Ask

Bioactivity:
O-GlcNAcase-IN-2 (compound 81) is an orally active, brain-penetrant inhibitor of O-GlcNAcase, demonstrating an IC50 value of 4.93 nM. It has shown potential in elevating protein O-GlcNAcylation levels and promoting phosphorylation of tau (p-Ser199, p-Thr205, p-Ser396) in an OA-impacted SH-SY5Y cell model. Additionally, O-GlcNAcase-IN-2 has been observed to ameliorate cognitive deficits in APP/PS1 mice, suggesting its potential utility in combating Alzheimer's disease (AD) .
Molecular Formula:
C22H26N4OS
Molecular Weight:
394.53
Shipping Conditions:
Cool pack
Storage Temperature:
-20°C

Related Products

CAT	Name
T89845-01	O-GlcNAcase-IN-2
T61662-01	O-GlcNAcase-IN-4
T60571	O-GlcNAcase-IN-1
T75232-01	2'-O-Acetyl-5'-O-benzoyl-3'-O- (2-methoxyethyl) uridine
TNU1394-01	2'-O-Acetyl-5'-O-benzoyl-3'-O- (2-methoxyethyl) uridine
T75228-01	6-O-Methyl-2'-O-methylinosine
T83401-01	2′-O-Methylphloretin
TN2786	2''-O-Galloylquercitrin
TN7106-01	2′-O-Methyluridine
TN2783	2-O-Acetyltutin

CAT	Name
HY-161953	O-GlcNAcase-IN-2
B2019345	O-GlcNAcase Enzyme
MBS5804363	O-GlcNAcase-IN-4
HY-176852	O-GlcNAcase-IN-3
MBS5803297	O-GlcNAcase-IN-1
TBI2406-25MG	PugNAc, O-GlcNAcase inhibitor
TBI2406-5MG	PugNAc, O-GlcNAcase inhibitor
MBS388891-01	OGA/O-GlcNAcase antibody (pAb)
abx376921-01	Protein O-Glcnacase (OGA) Antibody
bsm-54428R	O-GlcNAcase (1A5) Monoclonal Antibody