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O-GlcNAcase-IN-2

CAT: 0931-T89845-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89845-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
O-GlcNAcase-IN-2 (compound 81) is an orally active, brain-penetrant inhibitor of O-GlcNAcase, demonstrating an IC50 value of 4.93 nM. It has shown potential in elevating protein O-GlcNAcylation levels and promoting phosphorylation of tau (p-Ser199, p-Thr205, p-Ser396) in an OA-impacted SH-SY5Y cell model. Additionally, O-GlcNAcase-IN-2 has been observed to ameliorate cognitive deficits in APP/PS1 mice, suggesting its potential utility in combating Alzheimer's disease (AD) .
Molecular Formula
C22H26N4OS
Molecular Weight
394.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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