O-GlcNAcase-IN-2

CAT:

931-T89845-01

Size:

10 mg

Price:

Ask

Bioactivity :
O-GlcNAcase-IN-2 (compound 81) is an orally active, brain-penetrant inhibitor of O-GlcNAcase, demonstrating an IC50 value of 4.93 nM. It has shown potential in elevating protein O-GlcNAcylation levels and promoting phosphorylation of tau (p-Ser199, p-Thr205, p-Ser396) in an OA-impacted SH-SY5Y cell model. Additionally, O-GlcNAcase-IN-2 has been observed to ameliorate cognitive deficits in APP/PS1 mice, suggesting its potential utility in combating Alzheimer's disease (AD) .
Molecular Formula :
C22H26N4OS
Molecular Weight :
394.53
Shipping Conditions :
Cool pack
Storage Temperature :
-20°C

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