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TQ05310

CAT: 0931-T89839-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89839-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2071196-10-4
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolism
Bioactivity
TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.
Smiles
FC(F)(F)C1=NC(=CC=C1)C2=NC(=NOC(C)(C)C)N=C(N2)NC=3C=CN=C(C3)C(F)(F)F
Molecular Formula
C19H17F6N7O
Molecular Weight
473.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19238246-01TQ05310

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