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DC371739

CAT: 0931-T88735-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T88735-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2135765-21-6
Target
ANGPTL
Related Pathways
Proteases/Proteasome, Metabolism
Bioactivity
DC371739 is an effective oral PCSK9 inhibitor that decreases both PCSK9 and ANGPTL3 mRNA expression. It also reduces PCSK9 protein expression while enhancing that of LDLR. Given its properties, DC371739 has potential applications in the study of hyperlipidemia.
Smiles
OCN1C=2C=CC(OC)=CC2C3=C1CN4CCC5=CC(OCC=6C=CC=CC6)=C(OC)C=C5C4C3
Molecular Formula
C29H30N2O4
Molecular Weight
470.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 131978513
CAS Number2135765-21-6
PubChem CID131978513
IUPAC Name(6,19-dimethoxy-18-phenylmethoxy-10,13-diazapentacyclo[11.8.0.03,11.04,9.016,21]henicosa-3(11),4(9),5,7,16,18,20-heptaen-10-yl)methanol
Molecular FormulaC29H30N2O4
Molecular Weight470.6
XLogP4.2
Topological Polar Surface Area56.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity702
SMILES
COC1=CC2=C(C=C1)N(C3=C2CC4C5=CC(=C(C=C5CCN4C3)OCC6=CC=CC=C6)OC)CO
InChI
InChI=1S/C29H30N2O4/c1-33-21-8-9-25-23(13-21)24-14-26-22-15-28(34-2)29(35-17-19-6-4-3-5-7-19)12-20(22)10-11-30(26)16-27(24)31(25)18-32/h3-9,12-13,15,26,32H,10-11,14,16-18H2,1-2H3
InChIKey
DEEWVZQNTLFSBJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 131978513
CAS: 2135765-21-6
CID: 131978513
Formula: C29H30N2O4
MW: 470.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.6
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass470.22055744
Monoisotopic Mass470.22055744
Topological Polar Surface Area56.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity702
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-163794-01DC371739

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