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TG8-260

CAT: 0931-T88625-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T88625-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2490544-50-6
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein|||Immunology/Inflammation
Bioactivity
TG8-260 is a second-generation EP2 antagonist developed to mitigate pathology in inflammatory-driven central and peripheral nervous system disorders. In a rat model, TG8-260 reduced neuroinflammation and gliosis in the hippocampal region following pilocarpine-induced status epilepticus. Pharmacokinetic data for TG8-260 reveal a plasma half-life of 2.14 hours and an oral bioavailability of 77.3%. Furthermore, TG8-260 acts as a potent inhibitor of CYP450 and demonstrates antagonistic activity by inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglial cells, making it suitable for research on anti-inflammatory pathways in animal models of peripheral inflammatory diseases.
Smiles
O=C(NCCC=1C=2C=CC=CC2NC1C)C=3C=CC(=CC3)C4=CN=CN4
Molecular Formula
C21H20N4O
Molecular Weight
344.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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