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WRX606

CAT: 0931-T88488-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88488-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
899937-47-4
Target
MTOR
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
WRX606 is an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) . In MCF-7 cells, it inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (p-S6K1) with an IC50 value of 10 nM, and the phosphorylation of eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) with an IC50 of 0.27 μM. Additionally, WRX606 exhibits cytotoxicity in HepG2 cells with an IC50 of 17 nM and has demonstrated antitumor efficacy in mouse models.
Smiles
O=C(NC=1C=CC=C(Cl)C1)CN2C(=O)N(C(=O)C=3C=CC=CC32)CCCC(=O)NCC4=CC=C5OCOC5=C4
Molecular Formula
C28H25ClN4O6
Molecular Weight
548.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19236547-01WRX606

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