Products for Research Use Only
RegisterLogin

RG7112D

CAT: 0931-T88196-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T88196-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2360561-90-4
Target
MDM-2/p53
Related Pathways
Apoptosis
Bioactivity
RG7112D is a potent MDM2 inhibitor, effectively inhibiting MDM2-p53 and VHL-HIF1α interactions with IC50 values of 11 nM and >10000 nM, respectively, as determined by HTRF binding assays. It couples with VHL-Amine via an amide bond to form the bifunctional molecule YX-02-030. YX-02-030 acts as an MDM2-PROTAC, efficiently blocking MDM2-p53 binding (HTRF IC50= 63 nM) . Additionally, RG7112D stabilizes MDM2 protein and enhances p53 protein levels.
Smiles
C[C@@]1(N(C(=O)N2CCN(CC(O)=O)CC2)C(=N[C@@]1(C)C3=CC=C(Cl)C=C3)C4=C(OCC)C=C(C(C)(C)C)C=C4)C5=CC=C(Cl)C=C5
Molecular Formula
C36H42Cl2N4O4
Molecular Weight
665.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T6965-01RG7112

Alternative Products

CatalogName
GTR19234019-01RG7112D

Popular Products