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NEO214

CAT: 0931-T86992-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86992-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361198-80-2
Target
MTOR, Autophagy
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling
Bioactivity
NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy/autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma [1].
Smiles
C(OCC=1CC[C@H](C(C)=C)CC1)(=O)N2CC(CC2=O)C3=CC(OC4CCCC4)=C(OC)C=C3
Molecular Formula
C27H35NO5
Molecular Weight
453.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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