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LBA-3

CAT: 0931-T86803-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86803-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2918263-09-7
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA) -stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].
Smiles
C(CC(CC(O)=O)(C(O)=O)O)C1=CC=C(C=C1)C2=CC=CC=C2
Molecular Formula
C18H18O5
Molecular Weight
314.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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