Products for Research Use Only
RegisterLogin

KIN-8194

CAT: 0931-T86782-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T86782-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
330786-01-1
Target
BTK, Src
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
KIN-8194 is a dual inhibitor of HCK and BTK, effective when administered orally, displaying IC 50 values of 0.915 nM for HCK and <0.495 nM for BTK. It inhibits growth and disrupts integrin-mediated adhesion in BTKi-resistant mantle cell lymphoma (MCL) . Additionally, KIN-8194 has shown efficacy in overcoming ibrutinib resistance, enhancing survival in TMD-8 ABC DLBCL xenografted mice [1] [2].
Smiles
NC1=C2C(=NN(C2=NC=N1)[C@@H]3CC[C@H](CC3)N4CCN(C)CC4)C5=CC=C(OC6=CC=CC=C6)C=C5
Molecular Formula
C28H33N7O
Molecular Weight
483.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T211183-01KIN-8741
T9901A-1021-01VIR-8190
T26612-01AM-8191 HCl
T31219DBM-819

Alternative Products

CatalogName
BA8816-10KIN-8194
HY-15805A-01Cis-KIN-8194
pro-1275KIN
GTR17983047Kin Antibody
C4148-100KIN-59
555218KIN-1148
DF13972-BPKIN Peptide
530976-01KIN discontinued
OM302804-01KIN Human
M14529-01KIN-1400

Popular Products