JAB-2485

• CAS Number :

  2899209-55-1

• Target :

  Aurora Kinase|||Apoptosis

• Related Pathways :

  Cell Cycle/Checkpoint|||Apoptosis|||Chromatin/Epigenetic

• Bioactivity :

  JAB-2485 is a highly potent and selective inhibitor of Aurora kinase A (AURKA), boasting an IC 50 of 0.33 nM, and demonstrates approximately 1700-fold selectivity for AURKA over AURKB. It induces cell cycle arrest and apoptosis, making it a valuable compound for cancer research [1].

• Smiles :

  C([C@]1(C(O)=O)C[C@@H](C)N(CC2=C(F)C(Cl)=CC=C2)CC1)C=3N=C(NC=4NN=C(C)C4)C(F)=C(C)C3

• Molecular Formula :

  C25H28ClF2N5O2

• Molecular Weight :

  503.97

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C