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JAB-2485

CAT: 0931-T86753-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86753-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2899209-55-1
Target
Aurora Kinase, Apoptosis
Related Pathways
Cell Cycle/Checkpoint, Apoptosis, Chromatin/Epigenetic
Bioactivity
JAB-2485 is a highly potent and selective inhibitor of Aurora kinase A (AURKA), boasting an IC 50 of 0.33 nM, and demonstrates approximately 1700-fold selectivity for AURKA over AURKB. It induces cell cycle arrest and apoptosis, making it a valuable compound for cancer research [1].
Smiles
C([C@]1(C(O)=O)C[C@@H](C)N(CC2=C(F)C(Cl)=CC=C2)CC1)C=3N=C(NC=4NN=C(C)C4)C(F)=C(C)C3
Molecular Formula
C25H28ClF2N5O2
Molecular Weight
503.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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