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HPO-DAEE

CAT: 0931-T86592-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86592-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1895934-61-8
Target
ROS, Reactive Oxygen Species, HDAC
Related Pathways
DNA Damage/DNA Repair, Metabolism, Immunology/Inflammation, Chromatin/Epigenetic, NF-κB
Bioactivity
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) performs multiple roles in cellular processes, primarily enhancing nuclear accumulation of Nrf2 and activating the antioxidant response element (ARE) . It upregulates antioxidant genes such as HO-1 through Nrf2-ARE signaling and initiates the generation of reactive oxygen species. Additionally, HPO-DAEE inhibits histone deacetylase, promoting the expression of extracellular superoxide dismutase via histone acetylation. It offers protection against 6-hydroxydopamine-induced cell death by activating the Nrf2-ARE and eIF2α-ATF4 pathways [1].
Smiles
C(C=CC(OCC)=O)(CCCCCC)OO
Molecular Formula
C12H22O4
Molecular Weight
230.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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