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Enpp-1-IN-19

CAT: 0931-T86370-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86370-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2738583-25-8
Target
PDE, STING
Related Pathways
Metabolism, Immunology/Inflammation
Bioactivity
Enpp-1-IN-19 (compound 29f) is an orally active inhibitor of ENPP1 that effectively blocks cGAMP hydrolysis with an IC50 of 68 nM. It not only enhances anti-PD-L1 responses and curtails tumor growth in CT26 syngeneic models but also boosts STING-mediated type I interferon responses. Additionally, Enpp-1-IN-19 fosters immune memory and aids in preventing tumor recurrence [1].
Smiles
C(C=1C=2C(C(=O)N(C)N1)=CC=CC2)C3=CC=C(NS(N)(=O)=O)C=C3
Molecular Formula
C16H16N4O3S
Molecular Weight
344.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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