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CZL80

CAT: 0931-T86155-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T86155-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
313482-91-6
Target
Caspase
Related Pathways
Proteases/Proteasome, Apoptosis
Purity
0.9948
Bioactivity
CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
Smiles
O=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=C(C2)NC(=O)C=3SC=CC3
Molecular Formula
C19H14N2O4S
Molecular Weight
366.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-131204-01CZL80

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