CRT0066101

• Target:

  Apoptosis|||Pim|||Serine/threonin kinase

• Related Pathways:

  Apoptosis|||Chromatin/Epigenetic|||Cell Cycle/Checkpoint|||JAK/STAT signaling|||Metabolism

• Bioactivity:

  CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7?nM and demonstrates anticancer effects [2].

• Smiles:

  OC=1C(=CC(=CC1)C2=CN(C)N=C2)C=3N=C(NC[C@@H](CC)N)C=CN3

• Molecular Formula:

  C18H22N6O

• Molecular Weight:

  338.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  956123-34-5