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6K465

CAT: 0931-T85508-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T85508-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2702965-27-1
Target
C-Myc, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Purity
0.9978
Bioactivity
6K465 is a novel and potent small molecule inhibitor based on a pyrimidine scaffold that selectively targets Aurora A kinase.6K465 demonstrates superior ability to reduce the levels of the c-MYC and N-MYC oncoproteins compared to the established inhibitor alisertib; in a comprehensive analysis of its antiproliferative effects, the sensitivities of various small cell lung cancer (SCLC) and breast cancer cell lines to 6K465 were strongly correlated with the baseline protein expression levels of c-MYC and/or N-MYC.
Smiles
O=C(C=1C=CC=C(Cl)C1F)N2CCC(NC=3N=C(C=C(N3)N4CCN(CC)CC4)NC5=NNC(=C5)C)CC2
Molecular Formula
C26H33ClFN9O
Molecular Weight
542.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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