ML-252 hydrochloride

• Target:

  Others|||Cytochromes P450|||Potassium Channel

• Related Pathways:

  Metabolism|||Membrane transporter/Ion channel|||Others

• Bioactivity:

  ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S) -enantiomer, which is significantly more effective than both its (R) -enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.

• Smiles:

  N(C([C@@H](CC)C1=CC=CC=C1)=O)C2=C(C=CC=C2)N3CCCC3.Cl

• Molecular Formula:

  C20H24N2O?HCl

• Molecular Weight:

  344.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2309887-61-2