ML-252 hydrochloride

CAT: 0931-MF-0120278-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0120278-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2309887-61-2
Target
Others|||Cytochromes P450|||Potassium Channel
Related Pathways
Metabolism|||Membrane transporter/Ion channel|||Others
Bioactivity
ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S) -enantiomer, which is significantly more effective than both its (R) -enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.
Smiles
N(C([C@@H](CC)C1=CC=CC=C1)=O)C2=C(C=CC=C2)N3CCCC3.Cl
Molecular Formula
C20H24N2O?HCl
Molecular Weight
344.9
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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