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Dityrosine hydrochloride

CAT: 0931-T85073-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T85073-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2716849-01-1
Target
Others
Related Pathways
Others
Bioactivity
Dityrosine, an oxidation product of protein formed through the intermolecular cross-linking of tyrosyl radicals from the reactive oxygen species (ROS) and tyrosine interaction, is associated with decreased hippocampal expression of NMDA receptor subunits Nr1, Nr2a, and Nr2b when administered intragastrically at 320 μg/kg per day, leading to memory impairments in mice as evidenced by their performance in a novel object recognition test. Additionally, it raises fasting blood glucose levels while reducing plasma insulin levels and the pancreatic expression of insulin synthesis-related genes Ins2, Pdx1, and MafA. Increased dityrosine levels have been positively linked to a range of diseases, including autism spectrum disorder, cataracts, Alzheimer's disease, Parkinson's disease, atherosclerosis, and cystic fibrosis.
Smiles
OC=1C(=CC(CC(C(O)=O)N)=CC1)C2=CC(CC(C(O)=O)N)=CC=C2O.Cl
Molecular Formula
C18H20N2O6?2HCl
Molecular Weight
433.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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