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M04

CAT: 0931-T84969-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84969-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
875158-73-9
Target
Others, Immunology/Inflammation related, Interleukin, STING, TNF
Related Pathways
Others, Immunology/Inflammation, Apoptosis
Bioactivity
M04 acts as a stimulator of interferon genes (STING) agonist, effectively inducing IFN reporter gene expression in HEK293T cells equipped with wild-type human STING. Its activity is specific, not affecting HEK293T cells with the R71H-G230A-R293Q (HAQ) human STING variant or mouse RAW 264.7 cells, showcasing allelic- and species-dependent effects at a concentration of 75 μM. This compound also stimulates the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs) . At 50 μM, M04 enhances human monocyte-derived dendritic cells' expression of HLA-DR (MHC class II receptor) and co-stimulatory molecules CD40, CD80, and CD86, improving T cell cross-priming in an ex vivo assay.
Smiles
CN(C)c1sc(nc1S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)C1CCCCC1
Molecular Formula
C18H24N2O4S3
Molecular Weight
428.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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