5α-Androstan-3β-ol

• Target:

  Endogenous Metabolite|||Others

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  5?-Androstan-3?-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16?- and 6?-hydroxylase over 16?- or 7?-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.

• Smiles:

  C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)CCC4)[H])(CC[C@]1(C[C@@H](O)CC2)[H])[H])[H]

• Molecular Formula:

  C19H32O

• Molecular Weight:

  276.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1224-92-6