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5α-Androstan-3β-ol

CAT: 0931-T84963-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84963-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1224-92-6
Target
Endogenous Metabolite, Others
Related Pathways
Others, Metabolism
Bioactivity
5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 μM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 μM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 μM, compared to >150 μM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.
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C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)CCC4)[H])(CC[C@]1(C[C@@H](O)CC2)[H])[H])[H]
Molecular Formula
C19H32O
Molecular Weight
276.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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