Rp-dGTPαS

CAT: 0931-T84664-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T84664-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

80902-29-0

Target

Others, HIV Protease

Related Pathways

Others, Proteases/Proteasome, Microbiology/Virology

Bioactivity

Rp-dGTPαS, an enantiomer of the dNTPαS nucleotide, serves as the substrate for SAMHD1, a critical regulator of cellular dNTP levels that curtails the replication of viruses (HIV-1, etc.) in CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex facilitates the hydrolysis of Rp-dGQTPαS into 2'-deoxynucleosides and triphosphates [1].

Smiles

O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)S)[C@@H](O)C3)NC(N)=N1

Molecular Formula

C10H16N5O12P3S

Molecular Weight

523.25

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
BLG-D030-25	Rp-dGTP-α-S
HY-137618B	Rp-dGTPαS
BLG-D231-05	Rp-2′-F-dGTP-α-S
NU-266	DGTPγS
NU-424L	DGTPαS
MBS256319-01	2'- Deoxyguanosine- 5'- O- (1- thiotriphosphate), Rp- isomer (Rp-dGTP-alpha-S)
D 030-25	2'- Deoxyguanosine- 5'- O- (1- thiotriphosphate), Rp isomer (Rp-dGTP-α-S), sodium salt
JBS-NU-424S	DGTPαS, S pack
HY-137618	Sp-dGTPαS
HY-W784575A	DGTPαS (sodium)

Rp-dGTPαS

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