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(±) 5 (6) -DiHET

CAT: 0931-T84609-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84609-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
213382-49-1
Target
Others
Related Pathways
Others
Bioactivity
5 (6) -DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5 (6) -EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5 (6) -EET, facilitating its measurement by utilizing the compound's conversion to 5 (6) -δ-lactone in solution. Additionally, 5 (6) -DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia.
Smiles
C(C(C/C=C\C/C=C\C/C=C\CCCCC)O)(CCCC(O)=O)O
Molecular Formula
C20H34O4
Molecular Weight
338.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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