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URB447

CAT: 0931-T84488-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84488-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1132922-57-6
Target
Others, Cannabinoid Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].
Smiles
C(N1C(=C(N)C(C(=O)C2=CC=CC=C2)=C1C)C3=CC=CC=C3)C4=CC=C(Cl)C=C4
Molecular Formula
C25H21ClN2O
Molecular Weight
400.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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