F-Amidine TFA

CAT: 0931-T84479-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T84479-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

877617-46-4

Target

Others, PAD

Related Pathways

Chromatin/Epigenetic, Others

Bioactivity

F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 μM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.

Smiles

C(C(O)=O)(F)(F)F.C(N[C@@H](CCCNC(CF)=N)C(N)=O)(=O)C1=CC=CC=C1

Molecular Formula

C14H19FN4O2?CF3COOH

Molecular Weight

408.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-126560	F-Amidine
HY-126560A-01	F-Amidine (TFA)
GTR19232863-01	F-Amidine TFA
B2803-500	F-Amidine (trifluoroacetate salt)
MBS132938	Cl-Amidine

F-Amidine TFA

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