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LY303511 hydrochloride

CAT: 0931-T84382-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84382-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
854127-90-5
Target
Others, Potassium Channel, TNF
Related Pathways
Apoptosis, Membrane transporter/Ion channel, Others
Bioactivity
LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.
Smiles
Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
Molecular Formula
C19H20Cl2N2O2
Molecular Weight
379.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(4-Piperazinyl)-8-phenyl-4h-1-benzopyran-4-one dihydrochloride
CAS Number854127-90-5
PubChem CID73012448
IUPAC Name8-phenyl-2-piperazin-1-ylchromen-4-one;dihydrochloride
Molecular FormulaC19H20Cl2N2O2
Molecular Weight379.3
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity464
SMILES
C1CN(CCN1)C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl.Cl
InChI
InChI=1S/C19H18N2O2.2ClH/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14;;/h1-8,13,20H,9-12H2;2*1H
InChIKey
GUISTZFSXPSDQO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Piperazinyl)-8-phenyl-4h-1-benzopyran-4-one dihydrochloride
CAS: 854127-90-5
CID: 73012448
Formula: C19H20Cl2N2O2
MW: 379.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass378.0901833
Monoisotopic Mass378.0901833
Topological Polar Surface Area41.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity464
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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