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MOMBA

CAT: 0931-T83955Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0931-T83955Size:250 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
6880-04-2
Target
Others, GPCR
Related Pathways
Others, GPCR/G Protein, Endocrinology/Hormones
Bioactivity
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD) . It demonstrates selective inactivity towards wild-type hFFA2, hFFA3, and mouse FFA2 receptors. It efficiently inhibits forskolin-induced cAMP levels in cells equipped with the hFFA2-DREADD receptor, exhibiting enhanced potency and comparable efficacy to Sorbic acid. In transgenic mice containing the hFFA2-DREADD gene, MOMBA administration notably slows gut transit and facilitates a concentration-dependent enhancement of GLP-1 secretion from colonic crypts, all while being orally bioavailable.
Smiles
COC1=C(C)C=C(C=C1)C(O)=O
Molecular Formula
C9H10O3
Molecular Weight
166.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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