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Norbixin hydrate

CAT: 0931-T83915-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83915-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Others
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Others
Bioactivity
Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 μM in a cell-free assay. At a dosage of 47.7 mg/kg, norbixin effectively alleviates hyperglycemia, hyperinsulinemia, and insulin resistance, in addition to reducing serum lipid levels, cardiac thiobarbituric acid reactive substances (TBARS), and glutathione (GSH) in rat cardio-metabolic syndrome models. It also lowers serum levels of oxidized LDL, aortic protein oxidation, and the atherosclerotic area in a rabbit cholesterol-induced atherosclerosis model. Furthermore, norbixin, administered at 0.1 and 1 mg/kg per day, minimizes mercury-induced DNA damage in rat hepatocytes and leukocytes and prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD) .
Smiles
OC(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O)=O
Molecular Formula
C24H28O4.XH2O
Molecular Weight
380.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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