Plipastatin A1

• Target:

  Others|||Phospholipase

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  Plipastatin A1, a lipopeptide isolated from B. cereus, demonstrates enzyme inhibitory and immunosuppressant properties. It effectively inhibits enzymes phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD) with half-maximal inhibitory concentrations (IC50s) of 2.9, 1.3, and 1.4 µM, respectively. Additionally, at a concentration of 100 µg/ml, plipastatin A1 inhibits lipopolysaccharide (LPS) -induced B cell blastogenesis and T cell blastogenesis triggered by concanavalin A. In vivo studies reveal that a dose of 0.1 mg/animal effectively suppresses delayed-type hypersensitivity in mice.

• Smiles:

  O=C ([C@H] (NC ([C@@H] (NC (C[C@@H] (CCCCCCCCCCCCC) O) =O) CCC (O) =O) =O) CCCN) N[C@@H] (CC1=CC=C (OC ([C@@] ([C@@H] (C) CC) ([H]) NC ([C@@H] (CC2=CC=C (O) C=C2) NC3=O) =O) =O) C=C1) C (N[C@@] ([C@H] (O) C) ([H]) C (N[C@@H] (CCC (O) =O) C (N[C@H] (C) C (N4[C@@] (C (N[C@H]3CCC (N) =O) =O) ([H]) CCC4) =O) =O) =O) =O

• Molecular Formula:

  C72H110N12O20

• Molecular Weight:

  1463.71

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  103651-09-8