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LAU-0901

CAT: 0931-T83777-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T83777-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
727358-25-0
Target
PAFR
Related Pathways
GPCR/G Protein
Bioactivity
LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO) -induced cerebral ischemia, at doses of 30, 60, and 90 mg/kg. Furthermore, it diminishes microglial infiltration while promoting astrocytic and neuronal survival in the same model. Additionally, at a dose of 30 mg/kg, LAU-0901, either alone or combined with atorvastatin, shows a capability to inhibit tumor growth in a U87MG glioblastoma mouse orthotopic tumor model.
Smiles
O=C(C1=C(C)NC(C)=C(C1C)C(OC(CN2CCOCC2)CN3CCOCC3)=O)OCCOC4=CC=C(C(Cl)=C4)Cl
Molecular Formula
C29H39Cl2N3O7
Molecular Weight
612.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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