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Moexiprilat

CAT: 0931-T83766-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T83766-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
103775-14-0
Target
Others, Angiotensin-converting Enzyme (ACE)
Related Pathways
Metabolism, Others
Bioactivity
Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it inhibits the proliferation of primary neonatal rat cardiac fibroblasts stimulated by estrone or angiotensin II. Furthermore, when given at a daily dosage of 50 mg/kg, moexiprilat reduces mean arterial blood pressure and elevates levels of atrial natriuretic peptide, an indicator of hypertension, in ovariectomized mice.
Smiles
C[C@H](N[C@H](C(O)=O)CCC1=CC=CC=C1)C(N2CC3=CC(OC)=C(OC)C=C3C[C@H]2C(O)=O)=O
Molecular Formula
C25H30N2O7
Molecular Weight
470.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
456414-01Moexiprilat
sc-484862Moexiprilat Hydrochloride
GEC84008-01Moexiprilat-d5
MM11755Moexiprilat acyl D-glucuronide
sc-218865Moexiprilat Acyl-β-D-glucuronide, >65%
M4320-26Moexiprilat-d5 (2-[2- (1-Carboxy-3-phenyl-d5-propylamino) -propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid)
MBS6055977-01Moexiprilat Hydrate (2-[2- (1-Carboxy-3-phenyl-propylamino) -propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid Hydrate)

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