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α-Helical CRF (9-41) TFA

CAT: 0931-T83665-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83665-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 μM, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 μmol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 μmol/kg in rats and demonstrates the ability to enhance social interaction times in a rat model addressing nicotine-induced conditioned anxiety, in addition to decreasing binge-like ethanol consumption in mice.
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OC(CC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H](NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H](CC(O)=O)N[H])=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C166H274N46O53S2.XCF3COOH
Molecular Weight
3826.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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