ARI-1

CAT: 0931-MF-0063169-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0063169-01Size:5 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||Others|||ROR
Related Pathways
Apoptosis|||Metabolism|||Others
Bioactivity
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant ROR1 expression linked to non-small cell lung cancer (NSCLC) and EGFR-TKI-induced drug resistance. It modulates PI3K/AKT/mTOR signaling pathways in a ROR1-dependent manner and demonstrates potent inhibition of NSCLC cell proliferation and migration, exhibiting antitumor activity in vivo [1].
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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