ARI-1

CAT: 0931-T82971-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T82971-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, Others, ROR

Related Pathways

Apoptosis, Metabolism, Others

Bioactivity

ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant ROR1 expression linked to non-small cell lung cancer (NSCLC) and EGFR-TKI-induced drug resistance. It modulates PI3K/AKT/mTOR signaling pathways in a ROR1-dependent manner and demonstrates potent inhibition of NSCLC cell proliferation and migration, exhibiting antitumor activity in vivo [1].

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS5824621	ARI-1
HY-139534A-01	(S) -ARI-1
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