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HQ005

CAT: 0931-T82177-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T82177-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2750644-31-4
Target
Others, Molecular Glues, CDK
Related Pathways
Others, Cell Cycle/Checkpoint, PROTAC
Bioactivity
HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 μM and functions as a molecular-glue degrader. By mediating interactions between target proteins and the ubiquitin-proteasome system, it facilitates selective protein degradation [1].
Smiles
O=C(NC1=NC=C(S1)C)CC=2N=C(SC2)NC=3N=C(C=CC3)CO
Molecular Formula
C15H15N5O2S2
Molecular Weight
361.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(2-{[6-(hydroxymethyl)pyridin-2-yl]amino}-1,3-thiazol-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide
CAS Number2750644-31-4
PubChem CID165665550
IUPAC Name2-[2-[[6-(hydroxymethyl)-2-pyridinyl]amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
Molecular FormulaC15H15N5O2S2
Molecular Weight361.4
XLogP1.8
Topological Polar Surface Area157
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count24
Formal Charge0
Complexity431
SMILES
CC1=CN=C(S1)NC(=O)CC2=CSC(=N2)NC3=CC=CC(=N3)CO
InChI
InChI=1S/C15H15N5O2S2/c1-9-6-16-14(24-9)20-13(22)5-11-8-23-15(18-11)19-12-4-2-3-10(7-21)17-12/h2-4,6,8,21H,5,7H2,1H3,(H,16,20,22)(H,17,18,19)
InChIKey
RCCDIUZAPKBQLV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-{[6-(hydroxymethyl)pyridin-2-yl]amino}-1,3-thiazol-4-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide
CAS: 2750644-31-4
CID: 165665550
Formula: C15H15N5O2S2
MW: 361.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight361.4
XLogP31.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass361.06671709
Monoisotopic Mass361.06671709
Topological Polar Surface Area157 Ų
Heavy Atom Count24
Formal Charge0
Complexity431
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5823829HQ005

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