MS6105

CAT: 0931-T81747-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T81747-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2891709-58-1

Target

PROTACs

Related Pathways

PROTAC

Bioactivity

MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Additionally, as a click chemistry reagent possessing an Alkyne group, MS6105 can partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-bearing molecules.

Smiles

C(C1=C(CC2CC2)N(N=C1C3=CC(C#CCCCCNC(CCCCCCCCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)=CC=C3)C7=NC(C(O)=O)=CS7)C8=CC=C(S(N)(=O)=O)C=C8

Molecular Formula

C65H81N9O9S3

Molecular Weight

1228.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MS6105

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