Retrocyclin-1

• Target:

  HIV Protease|||P-gp

• Related Pathways:

  Membrane transporter/Ion channel|||Microbiology/Virology|||Neuroscience|||Proteases/Proteasome

• Bioactivity:

  Retrocyclin-1, a Theta-defensin, selectively binds to carbohydrate-rich surface molecules such as fetuin, gp120 (K d =35.4 nM), CD4 (K d =31 nM), and galactosylceramide (K d =24.1 nM) [1], thereby shielding cells from HIV-1 infection.

• Smiles:

  O=C1[C@]2 (NC (=O) [C@H] (CCCNC (=N) N) NC (=O) [C@]3 (NC (=O) [C@] ([C@H] (CC) C) (NC (=O) CNC (=O) [C@H] (CCCNC (=N) N) NC (=O) CNC (=O) [C@] (CSSC3) (NC (=O) [C@] ([C@H] (CC) C) (NC (=O) [C@] (CSSC2) (NC (=O) [C@H] (CCCNC (=N) N) NC (=O) [C@@]4 (CSSC[C@] (NC (=O) [C@] ([C@H] (CC) C) (N1) [H]) (C (=O) NCC (=O) N[C@@H] (CCCNC (=N) N) C (=O) NCC (=O) N[C@@] ([C@H] (CC) C) (C (=O) N4) [H]) [H]) [H]) [H]) [H]) [H]) [H]) [H]) [H]

• Molecular Formula:

  C74H128N30O18S6

• Molecular Weight:

  1918.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  724760-19-4