SPLA2-IIA Inhibitor

CAT: 0931-T81115-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T81115-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

236394-37-9

Bioactivity

The sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK, specifically cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2), which interacts with human IIA phospholipase A2 (hGIIA) to impede its ester bond hydrolyzing function. As part of the esterase superfamily, sPLA2 enzymatically cleaves the sn-2 ester bond in glycerophospholipids, releasing arachidonic acid and lysophospholipids[1].

Smiles

C(C1=CC2=C(C=C1)C=CC=C2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC3=O

Molecular Formula

C41H50N8O6

Molecular Weight

750.89

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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SPLA2-IIA Inhibitor

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