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Azemiopsin

CAT: 0931-T80460-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T80460-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1391936-86-9
Target
AChR
Related Pathways
Neuroscience
Bioactivity
Azemiopsin, a potent inhibitor of the nicotinic acetylcholine receptor (nAChR), demonstrates half maximal inhibitory concentrations (IC50s) of 0.18 μM for T. californica nAChR and 22 μM for human α7 nAChR. Moreover, it effectively blocks acetylcholine-induced currents in Xenopus oocytes that heterologously express human muscle-type nAChR [1].
Smiles
C([C@@H](C(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(=O)N3[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(NCC(=O)N5[C@H](C(N[C@H](C(=O)N6[C@H](C(=O)N7[C@H](C(N[C@H](C(=O)N8[C@H](C(N[C@H](C(=O)N9[C@H](C(N[C@H](C(=O)N%10[C@H](C(O)=O)CCC%10)CCCCN)=O)CCC9)CCCNC(=N)N)=O)CCC8)CCCNC(=N)N)=O)CCC7)CCC6)CCCNC(=N)N)=O)CCC5)=O)CCC(N)=O)=O)=O)CCC3)CCC2)CCCCN)=O)CCC1)NC([C@H](CC=%11C=%12C(NC%11)=CC=CC%12)NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(N)=O)=O)=O)C=%13C=%14C(NC%13)=CC=CC%14
Molecular Formula
C118H174N38O26
Molecular Weight
2540.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-P5823-01Azemiopsin

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