PF-07202954

• Target:

  Acyltransferase

• Related Pathways:

  Metabolism

• Bioactivity:

  PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against human DGAT2 and effectively reduces liver triglyceride content in a rat model fed on a Western diet [1].

• Smiles:

  O(C1=CC(C=2N=CC(C(N[C@H]3C[C@H](F)CNC3)=O)=CN2)=CN=C1)C4=C(OCC)C=CC=N4

• Molecular Formula:

  C22H23FN6O3

• Molecular Weight:

  438.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2639372-47-5