BQZ-485

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Bioactivity:

  BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction. This disruption impedes vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus, triggering subsequent paraptosis events [1].

• Smiles:

  O(CC1=CC(C)=CC(C)=C1)C=2C=C3[C@@]4(N(CCC3=CC2OCC5=CC(C)=CC(C)=C5)[C@@H](C)C[C@H](O)C4)[H]

• Molecular Formula:

  C32H39NO3

• Molecular Weight:

  485.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1906915-49-8