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YCH1899

CAT: 0931-T79667-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T79667-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PARP
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-resistant (Capan-1/TP) cells with IC50 values of 0.89 nM and 1.13 nM, respectively. Moreover, YCH1899 possesses favorable pharmacokinetic attributes in rats [1].
Molecular Formula
C25H18BrFN6O3
Molecular Weight
549.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19230367-01YCH1899

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